7ZWS

Crystal structure of human BCL6 BTB domain in complex with compound 13

Summary for 7ZWS

Entry DOI	10.2210/pdb7zws/pdb
Descriptor	B-cell lymphoma 6 protein, ALA-TRP-VAL-ILE-PRO-ALA, 2-[3-cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-2-phenyl-ethanoic acid, ... (7 entities in total)
Functional Keywords	inhibitor, cancer, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	15974.99
Authors	Collie, G.W.,Le Bihan, Y.-V.,van Montfort, R.L.M. (deposition date: 2022-05-19, release date: 2022-11-16, Last modification date: 2024-01-31)
Primary citation	Pierrat, O.A.,Liu, M.,Collie, G.W.,Shetty, K.,Rodrigues, M.J.,Le Bihan, Y.V.,Gunnell, E.A.,McAndrew, P.C.,Stubbs, M.,Rowlands, M.G.,Yahya, N.,Shehu, E.,Talbot, R.,Pickard, L.,Bellenie, B.R.,Cheung, K.J.,Drouin, L.,Innocenti, P.,Woodward, H.,Davis, O.A.,Lloyd, M.G.,Varela, A.,Huckvale, R.,Broccatelli, F.,Carter, M.,Galiwango, D.,Hayes, A.,Raynaud, F.I.,Bryant, C.,Whittaker, S.,Rossanese, O.W.,Hoelder, S.,Burke, R.,van Montfort, R.L.M. Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays. Sci Rep, 12:18633-18633, 2022 Cited by PubMed: 36329085 DOI: 10.1038/s41598-022-23264-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation