7ZVT

CryoEM structure of Ku heterodimer bound to DNA

7ZVT の概要

• エントリーDOI: 10.2210/pdb7zvt/pdb
• EMDBエントリー: 14986
• 分子名称: DNA (5'-D(P*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*TP*C)-3'), DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*T)-3'), X-ray repair cross-complementing protein 6, ... (5 entities in total)
• 機能のキーワード: nhej, ku70, ku80, dna damage, dna binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 162570.49

構造登録者

Hardwick, S.W.,Kefala-Stavridi, A.,Chirgadze, D.Y.,Blundell, T.L.,Chaplin, A.K. (登録日: 2022-05-17, 公開日: 2023-05-24, 最終更新日: 2023-12-06)

• 主引用文献: Kefala Stavridi, A.,Gontier, A.,Morin, V.,Frit, P.,Ropars, V.,Barboule, N.,Racca, C.,Jonchhe, S.,Morten, M.J.,Andreani, J.,Rak, A.,Legrand, P.,Bourand-Plantefol, A.,Hardwick, S.W.,Chirgadze, D.Y.,Davey, P.,De Oliveira, T.M.,Rothenberg, E.,Britton, S.,Calsou, P.,Blundell, T.L.,Varela, P.F.,Chaplin, A.K.,Charbonnier, J.B.; Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.; Nucleic Acids Res., 51:11732-11747, 2023; PubMed: 37870477; DOI: 10.1093/nar/gkad863

実験手法

ELECTRON MICROSCOPY (2.74 Å)