7ZT4

Structure of E8 TCR in complex with human MR1 bound to 6FP

Summary for 7ZT4

Entry DOI	10.2210/pdb7zt4/pdb
Descriptor	Major histocompatibility complex class I-related gene protein, Beta-2-microglobulin, TCR alpha, ... (6 entities in total)
Functional Keywords	mr1, tcr, 6-formylpterin, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	97967.07
Authors	Karuppiah, V.,Robinson, R.A. (deposition date: 2022-05-09, release date: 2023-06-28, Last modification date: 2024-02-07)
Primary citation	Chancellor, A.,Alan Simmons, R.,Khanolkar, R.C.,Nosi, V.,Beshirova, A.,Berloffa, G.,Colombo, R.,Karuppiah, V.,Pentier, J.M.,Tubb, V.,Ghadbane, H.,Suckling, R.J.,Page, K.,Crean, R.M.,Vacchini, A.,De Gregorio, C.,Schaefer, V.,Constantin, D.,Gligoris, T.,Lloyd, A.,Hock, M.,Srikannathasan, V.,Robinson, R.A.,Besra, G.S.,van der Kamp, M.W.,Mori, L.,Calogero, R.,Cole, D.K.,De Libero, G.,Lepore, M. Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses. J.Exp.Med., 220:-, 2023 Cited by PubMed: 37382893 DOI: 10.1084/jem.20221939 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation