7ZRY
Structure of the 2a splicing variant of the full-length human LSD1 bound to CoREST (delta305)
Summary for 7ZRY
Entry DOI | 10.2210/pdb7zry/pdb |
Descriptor | Isoform of Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total) |
Functional Keywords | demethylase, histone, splicing, epigenetics, flavoprotein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 115850.57 |
Authors | Caroli, J.,Mattevi, A. (deposition date: 2022-05-06, release date: 2022-08-03, Last modification date: 2024-01-31) |
Primary citation | Astro, V.,Ramirez-Calderon, G.,Pennucci, R.,Caroli, J.,Saera-Vila, A.,Cardona-Londono, K.,Forastieri, C.,Fiacco, E.,Maksoud, F.,Alowaysi, M.,Sogne, E.,Falqui, A.,Gonzalez, F.,Montserrat, N.,Battaglioli, E.,Mattevi, A.,Adamo, A. Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism. Iscience, 25:104665-104665, 2022 Cited by PubMed: 35856020DOI: 10.1016/j.isci.2022.104665 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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