7ZRB

Crystal structure of Beta-catenin Armadillo repeats domain in complex with the inhibitor RS6452

7ZRB の概要

• エントリーDOI: 10.2210/pdb7zrb/pdb
• 分子名称: Catenin beta-1, 4-bromanyl-~{N}-(3-pyridin-2-ylphenyl)benzenesulfonamide (3 entities in total)
• 機能のキーワード: beta-catenin, colon cancer, wnt pathway, cell adhesion
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 118345.85

構造登録者

Capelli, D.,Pochetti, G.,Montanari, R. (登録日: 2022-05-04, 公開日: 2023-05-17, 最終更新日: 2024-02-07)

• 主引用文献: Nalli, M.,Di Magno, L.,Wen, Y.,Liu, X.,D'Ambrosio, M.,Puxeddu, M.,Parisi, A.,Sebastiani, J.,Sorato, A.,Coluccia, A.,Ripa, S.,Di Pastena, F.,Capelli, D.,Montanari, R.,Masci, D.,Urbani, A.,Naro, C.,Sette, C.,Orlando, V.,D'Angelo, S.,Biagioni, S.,Bigogno, C.,Dondio, G.,Pastore, A.,Stornaiuolo, M.,Canettieri, G.,Liu, T.,Silvestri, R.,La Regina, G.; Novel N -(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the beta-Catenin Armadillo Repeats Domain as an Anticancer Agent.; Acs Pharmacol Transl Sci, 6:1087-1103, 2023; PubMed: 37470018; DOI: 10.1021/acsptsci.3c00092

実験手法

X-RAY DIFFRACTION (3.434 Å)