7ZPE

human branched Chain Keto Acid Dehydrogenase Kinase in complex with ligand

Summary for 7ZPE

• Entry DOI: 10.2210/pdb7zpe/pdb
• Descriptor: Branched-chain alpha-ketoacid dehydrogenase kinase, 1,2-ETHANEDIOL, 2-[(4-chlorophenyl)methylamino]-5-propyl-6~{H}-[1,2,4]triazolo[1,5-a]pyrimidin-7-one, ... (4 entities in total)
• Functional Keywords: histidine kinase allosteric inhibitor branched chain ketoacid metabolism, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 44879.82

Authors

Kack, H.,Wissler, L. (deposition date: 2022-04-27, release date: 2025-11-12)

• Primary citation: La Sala, G.,Kack, H.,Pfleger, C.,Nevin, P.,De vivo, M.,Hogner, A.,Tyrchan, C.,Gohlke, H.,Wissler, L.,Frolov, A.,Bohm, K.,Janet, J.-P.; Combining druggability, co-evolution and rigidity analysis to map functional pockets; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.64 Å)