7ZPB

Structure of hemiacetylated human butyrylcholinesterase upon reaction with 8-(3-(4-(prop-2-yn-1-yl)piperazin-1-yl)propoxy)quinoline-2-carbaldehyde

Summary for 7ZPB

• Entry DOI: 10.2210/pdb7zpb/pdb
• Descriptor: Cholinesterase, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: butyrylcholinesterase, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 63852.46

Authors

Denic, M.,Chioua, M.,Knez, D.,Gobec, S.,Nachon, F.,Marco-Contelles, J.L.,Brazzolotto, X. (deposition date: 2022-04-27, release date: 2023-02-01, Last modification date: 2024-02-07)

• Primary citation: Knez, D.,Diez-Iriepa, D.,Chioua, M.,Gottinger, A.,Denic, M.,Chantegreil, F.,Nachon, F.,Brazzolotto, X.,Skrzypczak-Wiercioch, A.,Meden, A.,Pislar, A.,Kos, J.,Zakelj, S.,Stojan, J.,Salat, K.,Serrano, J.,Fernandez, A.P.,Sanchez-Garcia, A.,Martinez-Murillo, R.,Binda, C.,Lopez-Munoz, F.,Gobec, S.,Marco-Contelles, J.; 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases.; Acta Pharm Sin B, 13:2152-2175, 2023; PubMed: 37250172; DOI: 10.1016/j.apsb.2023.01.013

Experimental method

X-RAY DIFFRACTION (2.31 Å)