7ZP2

Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with BDA-04

7ZP2 の概要

• エントリーDOI: 10.2210/pdb7zp2/pdb
• 分子名称: Aspartate carbamoyltransferase, tert-butyl N-[5-phenyl-3-(2-phenylethylcarbamoyl)thiophen-2-yl]carbamate, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: aspartate transcarbamoylase, plasmodium falciparum, fragment-based screening, inhibitor, malaria, transferase
• 由来する生物種: Plasmodium falciparum 3D7
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 242957.34

構造登録者

Wang, C.,Zhang, B.,Groves, M.R. (登録日: 2022-04-26, 公開日: 2022-08-24, 最終更新日: 2024-01-31)

• 主引用文献: Wang, C.,Zhang, B.,Kruger, A.,Du, X.,Visser, L.,Domling, A.S.S.,Wrenger, C.,Groves, M.R.; Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials.; J.Am.Chem.Soc., 144:19070-19077, 2022; PubMed: 36195578; DOI: 10.1021/jacs.2c08128

実験手法

X-RAY DIFFRACTION (2.292 Å)