7ZO5
L1 metallo-beta-lactamase in complex with a mecillinam degradation product
Summary for 7ZO5
Entry DOI | 10.2210/pdb7zo5/pdb |
Descriptor | Metallo-beta-lactamase L1, ZINC ION, (2~{R},4~{S})-2-[(1~{R})-2-(azepan-1-yl)-1-formamido-2-oxidanylidene-ethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ... (5 entities in total) |
Functional Keywords | antibiotic, ligand, zinc, antimicrobial protein |
Biological source | Stenotrophomonas maltophilia |
Total number of polymer chains | 1 |
Total formula weight | 29561.00 |
Authors | Hinchliffe, P.,Spencer, J. (deposition date: 2022-04-24, release date: 2023-03-08, Last modification date: 2024-02-07) |
Primary citation | Hinchliffe, P.,Calvopina, K.,Rabe, P.,Mojica, M.F.,Schofield, C.J.,Dmitrienko, G.I.,Bonomo, R.A.,Vila, A.J.,Spencer, J. Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products. J.Biol.Chem., 299:104606-104606, 2023 Cited by PubMed: 36924941DOI: 10.1016/j.jbc.2023.104606 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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