7ZNT
CRYSTAL STRUCTURE OF AT7 IN COMPLEX WITH THE SECOND BROMODOMAIN OF HUMAN BRD4 AND PVHL:ELONGINC:ELONGINB
Summary for 7ZNT
Entry DOI | 10.2210/pdb7znt/pdb |
Descriptor | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (6 entities in total) |
Functional Keywords | protac ternary complex, e3 ligase, protac, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 115004.70 |
Authors | Hughes, S.J.,Casement, R.,Ciulli, A. (deposition date: 2022-04-22, release date: 2022-09-14, Last modification date: 2024-02-07) |
Primary citation | Hanzl, A.,Casement, R.,Imrichova, H.,Hughes, S.J.,Barone, E.,Testa, A.,Bauer, S.,Wright, J.,Brand, M.,Ciulli, A.,Winter, G.E. Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. Nat.Chem.Biol., 19:323-333, 2023 Cited by PubMed: 36329119DOI: 10.1038/s41589-022-01177-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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