7ZN7
Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD
Summary for 7ZN7
Entry DOI | 10.2210/pdb7zn7/pdb |
EMDB information | 14802 |
Descriptor | DNA damage-binding protein 1, B27a, Signal transducer and activator of transcription, ... (4 entities in total) |
Functional Keywords | interferon, ubiquitin-proteasome system, cullin-ring ubiquitin ligases (crl), ddb1, dcafs, viral dcaf (vdcaf), cytomegalovirus, stat2, irf9, virus |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 267251.72 |
Authors | Lauer, S.,Spahn, C.M.T.,Schwefel, D. (deposition date: 2022-04-20, release date: 2022-11-09, Last modification date: 2024-07-24) |
Primary citation | Le-Trilling, V.T.K.,Banchenko, S.,Paydar, D.,Leipe, P.M.,Binting, L.,Lauer, S.,Graziadei, A.,Klingen, R.,Gotthold, C.,Burger, J.,Bracht, T.,Sitek, B.,Jan Lebbink, R.,Malyshkina, A.,Mielke, T.,Rappsilber, J.,Spahn, C.M.,Voigt, S.,Trilling, M.,Schwefel, D. Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. Embo J., 42:e112351-e112351, 2023 Cited by PubMed: 36762436DOI: 10.15252/embj.2022112351 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.78 Å) |
Structure validation
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