7ZMI
Crystal Structure of Unlinked NS2B_NS3 Protease from Zika Virus in Complex with Inhibitor MI-2113
Summary for 7ZMI
Entry DOI | 10.2210/pdb7zmi/pdb |
Descriptor | Serine protease subunit NS2B, Serine protease NS3, (2~{R})-6-[[(2~{S})-6-azanyl-2-[[(2~{S})-6-azanyl-2-(2-phenylethanoylamino)hexanoyl]amino]hexanoyl]amino]-2-carbamimidamido-hexanoic acid, ... (4 entities in total) |
Functional Keywords | flavivirin, serine protease, viral protein, ns2b-ns3, zika virus |
Biological source | Zika virus More |
Total number of polymer chains | 2 |
Total formula weight | 25465.68 |
Authors | Huber, S.,Steinmetzer, T. (deposition date: 2022-04-19, release date: 2022-12-28, Last modification date: 2024-02-07) |
Primary citation | Hammerschmidt, S.J.,Huber, S.,Braun, N.J.,Lander, M.,Steinmetzer, T.,Kersten, C. Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs. Arch Pharm, 356:e2200518-e2200518, 2023 Cited by PubMed: 36480352DOI: 10.1002/ardp.202200518 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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