7ZM1

Crystal structure of HsaD from Mycobacterium tuberculosis in complex with Cyclophostin-like inhibitor CyC7b

Summary for 7ZM1

• Entry DOI: 10.2210/pdb7zm1/pdb
• Related: 7ZJT
• Descriptor: 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase, methoxy-[(~{E},3~{R})-3-[(2~{R})-1-methoxy-1,3-bis(oxidanylidene)butan-2-yl]tridec-11-enyl]phosphinous acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hsad, m. tuberculosis, cholesterol, inhibitor, hydrolase
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 2
• Total formula weight: 67234.40

Authors

Barelier, S.,Roig-Zamboni, V.,Cavalier, J.F.,Sulzenbacher, G. (deposition date: 2022-04-19, release date: 2022-09-28, Last modification date: 2024-02-07)

• Primary citation: Barelier, S.,Avellan, R.,Gnawali, G.R.,Fourquet, P.,Roig-Zamboni, V.,Poncin, I.,Point, V.,Bourne, Y.,Audebert, S.,Camoin, L.,Spilling, C.D.,Canaan, S.,Cavalier, J.F.,Sulzenbacher, G.; Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis.; Febs J., 290:1563-1582, 2023; PubMed: 36197115; DOI: 10.1111/febs.16645

Experimental method

X-RAY DIFFRACTION (2.15 Å)