7ZLD

Crystal Structure of Unlinked NS2B_NS3 Protease from Zika Virus in Complex with Inhibitor MI-2223

Summary for 7ZLD

Entry DOI	10.2210/pdb7zld/pdb
Descriptor	Serine protease subunit NS2B, Serine protease NS3, (2~{S})-2-[2-[3-(aminomethyl)phenyl]ethanoylamino]-6-azanyl-~{N}-[(2~{S})-6-azanyl-1-[[(5~{R})-6-azanyl-5-carbamimidamido-6-oxidanylidene-hexyl]amino]-1-oxidanylidene-hexan-2-yl]hexanamide, ... (4 entities in total)
Functional Keywords	flavivirin, serine protease, viral protein, ns2b-ns3, zika virus
Biological source	Zika virus More
Total number of polymer chains	2
Total formula weight	25493.74
Authors	Huber, S.,Steinmetzer, T. (deposition date: 2022-04-14, release date: 2022-12-28, Last modification date: 2024-02-07)
Primary citation	Hammerschmidt, S.J.,Huber, S.,Braun, N.J.,Lander, M.,Steinmetzer, T.,Kersten, C. Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs. Arch Pharm, 356:e2200518-e2200518, 2023 Cited by PubMed: 36480352 DOI: 10.1002/ardp.202200518 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation