7ZKC

Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum (apo form)

Summary for 7ZKC

• Entry DOI: 10.2210/pdb7zkc/pdb
• Related: 6FSN 7ZHB
• Descriptor: UDP-glucose-glycoprotein glucosyltransferase-like protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: glycoprotein, misfolding, transferase, endoplasmic reticulum. udp-glucose, gt24
• Biological source: Chaetomium thermophilum
• Total number of polymer chains: 1
• Total formula weight: 35951.85

Authors

Roversi, P.,Zitzmann, N.,Bayo, Y.,Le Cornu, J.D. (deposition date: 2022-04-12, release date: 2022-04-20, Last modification date: 2024-01-31)

• Primary citation: Guay, K.P.,Ibba, R.,Kiappes, J.L.,Vasiljevic, S.,Boni, F.,De Benedictis, M.,Zeni, I.,Le Cornu, J.D.,Hensen, M.,Chandran, A.V.,Kantsadi, A.L.,Caputo, A.T.,Blanco Capurro, J.I.,Bayo, Y.,Hill, J.C.,Hudson, K.,Lia, A.,Brun, J.,Withers, S.G.,Marti, M.,Biasini, E.,Santino, A.,De Rosa, M.,Milani, M.,Modenutti, C.P.,Hebert, D.N.,Zitzmann, N.,Roversi, P.; A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint.; Iscience, 26:107919-107919, 2023; PubMed: 37822503; DOI: 10.1016/j.isci.2023.107919

Experimental method

X-RAY DIFFRACTION (1.769 Å)