7ZHN

Crystal structure of TTBK1 in complex with AMG28

Summary for 7ZHN

• Entry DOI: 10.2210/pdb7zhn/pdb
• Descriptor: Tau-tubulin kinase 1, PHOSPHATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: kinase, ttbk1, tau tubulin kinase 1, inhibitor complex, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 36314.81

Authors

Chaikuad, A.,Axtman, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-04-06, release date: 2023-04-19, Last modification date: 2024-02-07)

• Primary citation: Bashore, F.M.,Marquez, A.B.,Chaikuad, A.,Howell, S.,Dunn, A.S.,Beltran, A.A.,Smith, J.L.,Drewry, D.H.,Beltran, A.S.,Axtman, A.D.; Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.; Sci Rep, 13:6118-6118, 2023; PubMed: 37059819; DOI: 10.1038/s41598-023-32854-4

Experimental method

X-RAY DIFFRACTION (1.85 Å)