7ZBV

Crystal structure of the peptidase domain of collagenase G from Clostridium histolyticum in complex with a diphosphonate-based inhibitor

Summary for 7ZBV

Entry DOI	10.2210/pdb7zbv/pdb
Related	2y6i
Descriptor	Collagenase ColG, ZINC ION, [6,7-bis(chloranyl)-3-phosphono-quinoxalin-2-yl]phosphonic acid, ... (6 entities in total)
Functional Keywords	collagenase, diphosphonate, colg, inhibitor, complex, hydrolase
Biological source	Hathewaya histolytica
Total number of polymer chains	1
Total formula weight	48831.50
Authors	Schoenauer, E.,Brandstetter, H. (deposition date: 2022-03-24, release date: 2022-11-09, Last modification date: 2024-01-31)
Primary citation	Alhayek, A.,Abdelsamie, A.S.,Schonauer, E.,Camberlein, V.,Hutterer, E.,Posselt, G.,Serwanja, J.,Blochl, C.,Huber, C.G.,Haupenthal, J.,Brandstetter, H.,Wessler, S.,Hirsch, A.K.H. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J.Med.Chem., 65:12933-12955, 2022 Cited by PubMed: 36154055 DOI: 10.1021/acs.jmedchem.2c00785 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation