7ZBV
Crystal structure of the peptidase domain of collagenase G from Clostridium histolyticum in complex with a diphosphonate-based inhibitor
Summary for 7ZBV
Entry DOI | 10.2210/pdb7zbv/pdb |
Related | 2y6i |
Descriptor | Collagenase ColG, ZINC ION, [6,7-bis(chloranyl)-3-phosphono-quinoxalin-2-yl]phosphonic acid, ... (6 entities in total) |
Functional Keywords | collagenase, diphosphonate, colg, inhibitor, complex, hydrolase |
Biological source | Hathewaya histolytica |
Total number of polymer chains | 1 |
Total formula weight | 48831.50 |
Authors | Schoenauer, E.,Brandstetter, H. (deposition date: 2022-03-24, release date: 2022-11-09, Last modification date: 2024-01-31) |
Primary citation | Alhayek, A.,Abdelsamie, A.S.,Schonauer, E.,Camberlein, V.,Hutterer, E.,Posselt, G.,Serwanja, J.,Blochl, C.,Huber, C.G.,Haupenthal, J.,Brandstetter, H.,Wessler, S.,Hirsch, A.K.H. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J.Med.Chem., 65:12933-12955, 2022 Cited by PubMed: 36154055DOI: 10.1021/acs.jmedchem.2c00785 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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