7Z6L
Crystal structure of PROTAC 5 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB
Summary for 7Z6L
Entry DOI | 10.2210/pdb7z6l/pdb |
Descriptor | Probable global transcription activator SNF2L2, von Hippel-Lindau disease tumor suppressor, Elongin-C, ... (6 entities in total) |
Functional Keywords | bromodomain, protac complex, e3 ligase, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 56843.93 |
Authors | Roy, M.J.,Bader, G.,Farnaby, W.,Ciulli, A. (deposition date: 2022-03-12, release date: 2022-09-07, Last modification date: 2024-01-31) |
Primary citation | Kofink, C.,Trainor, N.,Mair, B.,Wohrle, S.,Wurm, M.,Mischerikow, N.,Roy, M.J.,Bader, G.,Greb, P.,Garavel, G.,Diers, E.,McLennan, R.,Whitworth, C.,Vetma, V.,Rumpel, K.,Scharnweber, M.,Fuchs, J.E.,Gerstberger, T.,Cui, Y.,Gremel, G.,Chetta, P.,Hopf, S.,Budano, N.,Rinnenthal, J.,Gmaschitz, G.,Mayer, M.,Koegl, M.,Ciulli, A.,Weinstabl, H.,Farnaby, W. A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13:5969-5969, 2022 Cited by PubMed: 36216795DOI: 10.1038/s41467-022-33430-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
Download full validation report