7YX8

Crystal structure of the AM0627 (E326A) inactive mutant in complex with PSGL-1-like bis-T glycopeptide and Zn2+

7YX8 の概要

• エントリーDOI: 10.2210/pdb7yx8/pdb
• 分子名称: Peptidase M60 domain-containing protein, PSGL-1-like bis-T glycopeptide, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose, ... (6 entities in total)
• 機能のキーワード: glycoprotease, mucinase, t antigen, tn antigen, am0627, hydrolase
• 由来する生物種: Akkermansia muciniphila; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 104512.30

構造登録者

Taleb, V.,Liao, Q.,Narimatsu, Y.,Garcia-Garcia, A.,Companon, I.,Borges, R.J.,Gonzalez-Ramirez, A.M.,Corzana, F.,Clausen, H.,Rovira, C.,Hurtado-Guerrero, R. (登録日: 2022-02-15, 公開日: 2022-07-20, 最終更新日: 2022-08-10)

• 主引用文献: Taleb, V.,Liao, Q.,Narimatsu, Y.,Garcia-Garcia, A.,Companon, I.,Borges, R.J.,Gonzalez-Ramirez, A.M.,Corzana, F.,Clausen, H.,Rovira, C.,Hurtado-Guerrero, R.; Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut.; Nat Commun, 13:4324-4324, 2022; PubMed: 35882872; DOI: 10.1038/s41467-022-32021-9

実験手法

X-RAY DIFFRACTION (1.5 Å)