7YVW

NMR determination of the 2:1 binding motif structure involving cytosine flipping out for the recognition of the CGG/CGG triad DNA

Summary for 7YVW

• Entry DOI: 10.2210/pdb7yvw/pdb
• Descriptor: DNA (5'-D(*CP*TP*AP*AP*CP*GP*GP*AP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*TP*CP*GP*GP*TP*TP*AP*G)-3'), 3-[3-[(7-methyl-1,8-naphthyridin-2-yl)carbamoyloxy]propylamino]propyl ~{N}-(7-methyl-1,8-naphthyridin-2-yl)carbamate (3 entities in total)
• Functional Keywords: gg mismatch, drug, complex, dna
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 7753.55

Authors

Furuita, K.,Yamada, T.,Sakurabayashi, S.,Nomura, M.,Kojima, C.,Nakatani, K. (deposition date: 2022-08-19, release date: 2023-06-14)

• Primary citation: Yamada, T.,Furuita, K.,Sakurabayashi, S.,Nomura, M.,Kojima, C.,Nakatani, K.; NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA.; Nucleic Acids Res., 50:9621-9631, 2022; PubMed: 36095126; DOI: 10.1093/nar/gkac740

Experimental method

SOLUTION NMR