7YMG
Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 2-({3-ethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}amino)-3-(1H-indol-3-yl)propan-1-ol
Summary for 7YMG
Entry DOI | 10.2210/pdb7ymg/pdb |
Descriptor | Bromodomain-containing protein 4, SODIUM ION, (2S)-2-[(3-ethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)amino]-3-(1H-indol-3-yl)propan-1-ol, ... (6 entities in total) |
Functional Keywords | brd4, bet inhibitor, complex, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 30999.40 |
Authors | |
Primary citation | Kim, J.H.,Pandit, N.,Yoo, M.,Park, T.H.,Choi, J.U.,Park, C.H.,Jung, K.Y.,Lee, B.I. Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study. Sci Rep, 13:10805-10805, 2023 Cited by PubMed: 37402749DOI: 10.1038/s41598-023-37527-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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