7YIX

The Cryo-EM Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (ScFv) Complex.

7YIX の概要

• エントリーDOI: 10.2210/pdb7yix/pdb
• EMDBエントリー: 33865
• 分子名称: Alkaline phosphatase, tissue-nonspecific isozyme, scFv, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: alkaline phosphatase, bone mineralization, catalytic network, hypophosphatasia, structural biology, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 174673.60

構造登録者

Yu, Y.T.,Yao, D.Q.,Zhang, Q.,Rao, B.,Xia, Y.,Lu, Y.,Qin, A.,Ma, P.X.,Cao, Y. (登録日: 2022-07-18, 公開日: 2023-08-16)

• 主引用文献: Yu, Y.,Rong, K.,Yao, D.,Zhang, Q.,Cao, X.,Rao, B.,Xia, Y.,Lu, Y.,Shen, Y.,Yao, Y.,Xu, H.,Ma, P.,Cao, Y.,Qin, A.; The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.; Nat Commun, 14:4048-4048, 2023; PubMed: 37422472; DOI: 10.1038/s41467-023-39833-3

実験手法

ELECTRON MICROSCOPY (2.96 Å)