7YCE

KRas G12C in complex with Compound 7b

Summary for 7YCE

Entry DOI	10.2210/pdb7yce/pdb
Descriptor	Isoform 2B of GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	oncoprotein-inhibitor complex, oncoprotein/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	20542.56
Authors	Amano, Y. (deposition date: 2022-07-01, release date: 2022-08-10, Last modification date: 2023-11-29)
Primary citation	Imaizumi, T.,Akaiwa, M.,Abe, T.,Nigawara, T.,Koike, T.,Satake, Y.,Watanabe, K.,Kaneko, O.,Amano, Y.,Mori, K.,Yamanaka, Y.,Nagashima, T.,Shimazaki, M.,Kuramoto, K. Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity. Bioorg.Med.Chem., 71:116949-116949, 2022 Cited by PubMed: 35926326 DOI: 10.1016/j.bmc.2022.116949 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation