7YC5

Cryo-EM structure of SARS-CoV-2 spike in complex with K202.B bispecific antibody

7YC5 の概要

• エントリーDOI: 10.2210/pdb7yc5/pdb
• EMDBエントリー: 33734
• 分子名称: Spike glycoprotein, Bispecific anitybody (scFv and light chain of the antibody), Heavy chain from K202.B antibody, ... (4 entities in total)
• 機能のキーワード: spike protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 706901.50

構造登録者

Yoo, Y.,Cho, H.S. (登録日: 2022-06-30, 公開日: 2023-07-05, 最終更新日: 2025-03-05)

• 主引用文献: Kim, J.W.,Heo, K.,Kim, H.J.,Yoo, Y.,Cho, H.S.,Jang, H.J.,Lee, H.Y.,Ko, I.Y.,Woo, J.R.,Cho, Y.B.,Lee, J.H.,Yang, H.R.,Shin, H.G.,Choi, H.L.,Hwang, K.,Kim, S.,Kim, H.,Chun, K.,Lee, S.; Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants; Antiviral Res., 212:105576-, 2023; DOI: 10.1016/j.antiviral.2023.105576

実験手法

ELECTRON MICROSCOPY (3.1 Å)