7Y7Y

Cryo-EM structure of human GABA transporter GAT1 bound with nipecotic acid in NaCl solution in an inward-occluded state at 2.4 angstrom

Summary for 7Y7Y

• Entry DOI: 10.2210/pdb7y7y/pdb
• Related: 7Y7V 7Y7W 7Y7X 7Y7Z
• EMDB information: 33671 33672 33673 33674 33675
• Descriptor: Sodium- and chloride-dependent GABA transporter 1, (3R)-piperidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: gaba transporter, gat1, nipecotic acid, tiagabine, neurotransmitter, slc6a1, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 71770.11

Authors

Zhu, A.,Huang, J.,Kong, F.,Tan, J.,Lei, J.,Yuan, Y.,Yan, C. (deposition date: 2022-06-22, release date: 2023-04-26, Last modification date: 2023-08-16)

• Primary citation: Zhu, A.,Huang, J.,Kong, F.,Tan, J.,Lei, J.,Yuan, Y.,Yan, C.; Molecular basis for substrate recognition and transport of human GABA transporter GAT1.; Nat.Struct.Mol.Biol., 30:1012-1022, 2023; PubMed: 37400655; DOI: 10.1038/s41594-023-00983-z

Experimental method

ELECTRON MICROSCOPY (2.4 Å)