7Y43

Crystal structure of the KAT6A WH domain and its bound double stranded DNA

7Y43 の概要

• エントリーDOI: 10.2210/pdb7y43/pdb
• 分子名称: Histone acetyltransferase KAT6A, DNA (5'-D(*GP*GP*AP*GP*TP*GP*CP*GP*CP*AP*CP*TP*CP*C)-3'), MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: cpg islands, winged-helix domain, acetyltransferase, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 18247.08

構造登録者

Wang, Z.,Jia, Y. (登録日: 2022-06-13, 公開日: 2023-01-18, 最終更新日: 2023-11-29)

• 主引用文献: Weber, L.M.,Jia, Y.,Stielow, B.,Gisselbrecht, S.S.,Cao, Y.,Ren, Y.,Rohner, I.,King, J.,Rothman, E.,Fischer, S.,Simon, C.,Forne, I.,Nist, A.,Stiewe, T.,Bulyk, M.L.,Wang, Z.,Liefke, R.; The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.; Nucleic Acids Res., 51:574-594, 2023; PubMed: 36537216; DOI: 10.1093/nar/gkac1188

実験手法

X-RAY DIFFRACTION (1.5 Å)