7Y06

Crystal structure of Ricin A chain bound with (S)-2-(2-amino-4-oxo-3,4-dihydropteridine-7-carboxamido)-4-phenylbutanoic acid

Summary for 7Y06

Entry DOI	10.2210/pdb7y06/pdb
Related	7XZS 7XZT 7XZU 7XZW 7Y02 7Y03 7Y05
Descriptor	Ricin A chain, (2S)-2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]-4-phenyl-butanoic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	hydrolase inhibitor, hydrolase
Biological source	Ricinus communis (castor bean)
Total number of polymer chains	1
Total formula weight	31825.63
Authors	Goto, M.,Higashi, S.,Ohba, T.,Kawata, R.,Nagatsu, K.,Suzuki, S.,Saito, R. (deposition date: 2022-06-03, release date: 2022-12-21, Last modification date: 2023-11-29)
Primary citation	Goto, M.,Higashi, S.,Ohba, T.,Kawata, R.,Nagatsu, K.,Suzuki, S.,Anslyn, E.V.,Saito, R. Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket. Biochem.Biophys.Res.Commun., 627:1-4, 2022 Cited by PubMed: 35998389 DOI: 10.1016/j.bbrc.2022.08.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation