7XZT

Crystal structure of Ricin A chain bound with (2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-D-tyrosine

Summary for 7XZT

• Entry DOI: 10.2210/pdb7xzt/pdb
• Related: 7XZS
• Descriptor: Ricin A chain, (2R)-2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]-3-(4-hydroxyphenyl)propanoic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hydrolase inhibitor, hydrolase
• Biological source: Ricinus communis (castor bean)
• Total number of polymer chains: 1
• Total formula weight: 31459.26

Authors

Goto, M.,Higashi, S.,Ohba, T.,Kawata, R.,Nagatsu, K.,Suzuki, S.,Saito, R. (deposition date: 2022-06-03, release date: 2022-12-21, Last modification date: 2023-11-29)

• Primary citation: Goto, M.,Higashi, S.,Ohba, T.,Kawata, R.,Nagatsu, K.,Suzuki, S.,Anslyn, E.V.,Saito, R.; Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.; Biochem.Biophys.Res.Commun., 627:1-4, 2022; PubMed: 35998389; DOI: 10.1016/j.bbrc.2022.08.008

Experimental method

X-RAY DIFFRACTION (1.3 Å)