7XW8

Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAK-418 distomer, FAD-adduct

Summary for 7XW8

• Entry DOI: 10.2210/pdb7xw8/pdb
• Related: 7E0G
• Descriptor: Lysine-specific histone demethylase 1A, GLYCEROL, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: inhibitor, tak-418, distomer, fad-adduct, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 75049.04

Authors

Oki, H. (deposition date: 2022-05-26, release date: 2022-10-12, Last modification date: 2023-11-29)

• Primary citation: Hattori, Y.,Matsumoto, S.,Morimoto, S.,Daini, M.,Toyofuku, M.,Matsuda, S.,Baba, R.,Murakami, K.,Iwatani, M.,Oki, H.,Iwasaki, S.,Matsumiya, K.,Tominari, Y.,Kimura, H.,Ito, M.; Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.; Eur.J.Med.Chem., 239:114522-114522, 2022; PubMed: 35749987; DOI: 10.1016/j.ejmech.2022.114522

Experimental method

X-RAY DIFFRACTION (2.28 Å)