7XP5
Cryo-EM structure of a class T GPCR in ligand-free state
Summary for 7XP5
Entry DOI | 10.2210/pdb7xp5/pdb |
EMDB information | 33365 |
Descriptor | Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(t) subunit alpha-3, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total) |
Functional Keywords | g protein-coupled receptor, taste type 2 receptors, cryo-electron microscopy structure, membrane protein |
Biological source | Acetivibrio thermocellus (Hungateiclostridium thermocellum) More |
Total number of polymer chains | 5 |
Total formula weight | 184561.11 |
Authors | |
Primary citation | Xu, W.,Wu, L.,Liu, S.,Liu, X.,Cao, X.,Zhou, C.,Zhang, J.,Fu, Y.,Guo, Y.,Wu, Y.,Tan, Q.,Wang, L.,Liu, J.,Jiang, L.,Fan, Z.,Pei, Y.,Yu, J.,Cheng, J.,Zhao, S.,Hao, X.,Liu, Z.J.,Hua, T. Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377:1298-1304, 2022 Cited by PubMed: 36108005DOI: 10.1126/science.abo1633 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.08 Å) |
Structure validation
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