7XMR

CryoEM structure of the somatostatin receptor 2 (SSTR2) in complex with Gi1 and its endogeneous peptide ligand SST-14

7XMR の概要

• エントリーDOI: 10.2210/pdb7xmr/pdb
• EMDBエントリー: 33302
• 分子名称: Somatostatin receptor type 2, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
• 機能のキーワード: g protein-coupled receptor, somatostatin receptor 2, cryo-em, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 133991.11

構造登録者

Wenli, Z.,Shuo, H.,Na, Q.,Wenbo, Z.,Mengjie, L.,Dehua, Y.,Ming-Wei, W.,Wu, B.,Zhao, Q. (登録日: 2022-04-26, 公開日: 2022-08-03, 最終更新日: 2022-08-17)

• 主引用文献: Zhao, W.,Han, S.,Qiu, N.,Feng, W.,Lu, M.,Zhang, W.,Wang, M.,Zhou, Q.,Chen, S.,Xu, W.,Du, J.,Chu, X.,Yi, C.,Dai, A.,Hu, L.,Shen, M.Y.,Sun, Y.,Zhang, Q.,Ma, Y.,Zhong, W.,Yang, D.,Wang, M.W.,Wu, B.,Zhao, Q.; Structural insights into ligand recognition and selectivity of somatostatin receptors.; Cell Res., 32:761-772, 2022; PubMed: 35739238; DOI: 10.1038/s41422-022-00679-x

実験手法

ELECTRON MICROSCOPY (3.1 Å)