7XM7

Crystal Structure of the CBP in complex with the Y08188

Summary for 7XM7

• Entry DOI: 10.2210/pdb7xm7/pdb
• Descriptor: CREB-binding protein, 3-ethanoyl-~{N}-[2-fluoranyl-3-(1-methylpyrazol-4-yl)phenyl]-7-methoxy-indolizine-1-carboxamide, GLYCEROL, ... (8 entities in total)
• Functional Keywords: bromodomain, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 64902.50

Authors

Xiang, Q.,Zhang, Y.,Wang, C.,Song, M.,Xu, Y. (deposition date: 2022-04-25, release date: 2022-06-22, Last modification date: 2023-11-29)

• Primary citation: Xiang, Q.,Zhang, Y.,Wang, C.,Song, M.,Xu, Y.; Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as potent and selective CBP bromodomain inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.36 Å)