7XKJ
Kras-G12D-GDP-MRTX1133 by FIB-MicroED
Summary for 7XKJ
Entry DOI | 10.2210/pdb7xkj/pdb |
Descriptor | KRAS proto-oncogene, GTPase, GUANOSINE-5'-DIPHOSPHATE, 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, ... (5 entities in total) |
Functional Keywords | oncoprotein, g12d, gdp, gtpase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor, microed |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 20381.87 |
Authors | Li, X.M. (deposition date: 2022-04-19, release date: 2023-08-02, Last modification date: 2023-08-16) |
Primary citation | Li, X.M. Kras-G12D-GDP-MRTX1133 by FIB-MicroED To Be Published, |
Experimental method | ELECTRON CRYSTALLOGRAPHY (3 Å) |
Structure validation
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