7XGK

Human renin in complex with compound1

Summary for 7XGK

• Entry DOI: 10.2210/pdb7xgk/pdb
• Descriptor: Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, UNKNOWN LIGAND, ... (4 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 74976.43

Authors

Kashima, A. (deposition date: 2022-04-05, release date: 2022-08-31)

• Primary citation: Iijima, D.,Sugama, H.,Awai, N.,Takahashi, Y.,Togashi, Y.,Takebe, T.,Xie, J.,Shen, J.,Ke, Y.,Akatsuka, H.,Kawaguchi, T.,Takedomi, K.,Kashima, A.,Nishio, M.,Inui, Y.,Yoneda, H.,Xia, G.,Iijima, T.; Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.; Acs Med.Chem.Lett., 13:1351-1357, 2022; PubMed: 35978678; DOI: 10.1021/acsmedchemlett.2c00280

Experimental method

X-RAY DIFFRACTION (2.4 Å)