7XGE
Crystal structure of MCL-1 in complex with computationally designed inhibitor protein
Summary for 7XGE
Entry DOI | 10.2210/pdb7xge/pdb |
Descriptor | BCL-xL and MCL-1 dual binder 2, Induced myeloid leukemia cell differentiation protein Mcl-1 (3 entities in total) |
Functional Keywords | computational design, apotosis, de novo protein |
Biological source | synthetic construct More |
Total number of polymer chains | 8 |
Total formula weight | 148067.21 |
Authors | |
Primary citation | Kim, S.,Park, H.S.,Oh, B.H. Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently. Comput Struct Biotechnol J, 20:3019-3029, 2022 Cited by PubMed: 35782728DOI: 10.1016/j.csbj.2022.06.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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