7XGE

Crystal structure of MCL-1 in complex with computationally designed inhibitor protein

7XGE の概要

• エントリーDOI: 10.2210/pdb7xge/pdb
• 分子名称: BCL-xL and MCL-1 dual binder 2, Induced myeloid leukemia cell differentiation protein Mcl-1 (3 entities in total)
• 機能のキーワード: computational design, apotosis, de novo protein
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 148067.21

構造登録者

Oh, B.-H.,Kim, S. (登録日: 2022-04-04, 公開日: 2022-07-20, 最終更新日: 2024-04-03)

• 主引用文献: Kim, S.,Park, H.S.,Oh, B.H.; Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently.; Comput Struct Biotechnol J, 20:3019-3029, 2022; PubMed: 35782728; DOI: 10.1016/j.csbj.2022.06.021

実験手法

X-RAY DIFFRACTION (2.38 Å)