7X8S

Cryo-EM structure of the WB4-24-bound hGLP-1R-Gs complex

7X8S の概要

• エントリーDOI: 10.2210/pdb7x8s/pdb
• EMDBエントリー: 33058
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: glucagon-like peptide-1 receptor, type 2 diabetes mellitus, peptidomimetic agonism, membrane protein
• 由来する生物種: Bos taurus (cattle); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 158583.80

構造登録者

Cong, Z.T.,Zhou, Q.T.,Li, Y.,Chen, L.N.,Zhang, Z.C.,Liang, A.Y.,Liu, Q.,Wu, X.Y.,Dai, A.T.,Xia, T.,Wu, W.,Zhang, Y.,Yang, D.H.,Wang, M.W. (登録日: 2022-03-14, 公開日: 2022-06-29)

• 主引用文献: Cong, Z.,Zhou, Q.,Li, Y.,Chen, L.N.,Zhang, Z.C.,Liang, A.,Liu, Q.,Wu, X.,Dai, A.,Xia, T.,Wu, W.,Zhang, Y.,Yang, D.,Wang, M.W.; Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24.; Proc.Natl.Acad.Sci.USA, 119:e2200155119-e2200155119, 2022; PubMed: 35561211; DOI: 10.1073/pnas.2200155119

実験手法

ELECTRON MICROSCOPY (3.09 Å)