7X73
Structure of G9a in complex with RK-701
Summary for 7X73
Entry DOI | 10.2210/pdb7x73/pdb |
Descriptor | Histone-lysine N-methyltransferase EHMT2, ZINC ION, SINEFUNGIN, ... (7 entities in total) |
Functional Keywords | histone lysine methyltransferase, inhibitor, protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 67697.32 |
Authors | Niwa, H.,Shirai, F.,Sato, S.,Nishigaya, Y.,Shirouzu, M.,Umehara, T. (deposition date: 2022-03-09, release date: 2022-12-21, Last modification date: 2023-11-29) |
Primary citation | Takase, S.,Hiroyama, T.,Shirai, F.,Maemoto, Y.,Nakata, A.,Arata, M.,Matsuoka, S.,Sonoda, T.,Niwa, H.,Sato, S.,Umehara, T.,Shirouzu, M.,Nishigaya, Y.,Sumiya, T.,Hashimoto, N.,Namie, R.,Usui, M.,Ohishi, T.,Ohba, S.I.,Kawada, M.,Hayashi, Y.,Harada, H.,Yamaguchi, T.,Shinkai, Y.,Nakamura, Y.,Yoshida, M.,Ito, A. A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nat Commun, 14:23-23, 2023 Cited by PubMed: 36635268DOI: 10.1038/s41467-022-35404-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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