7X1U

Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide Agonist TRH.

Summary for 7X1U

Entry DOI	10.2210/pdb7x1u/pdb
EMDB information	32950
Related PRD ID	PRD_002371
Descriptor	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Thyrotropin-releasing hormone receptor, mini-G alpha q prtoein, ... (6 entities in total)
Functional Keywords	thyrotropin-releasing hormone receptor, cryo-em, protirelin, agonist, membrane protein
Biological source	Bos taurus (cattle) More
Total number of polymer chains	6
Total formula weight	145509.60
Authors	Yang, F.,Zhang, H.H.,Meng, X.Y.,Li, Y.G.,Zhou, Y.X.,Ling, S.L.,Liu, L.,Shi, P.,Tian, C.L. (deposition date: 2022-02-24, release date: 2022-08-31, Last modification date: 2024-11-06)
Primary citation	Yang, F.,Zhang, H.,Meng, X.,Li, Y.,Zhou, Y.,Ling, S.,Sun, D.,Lv, P.,Liu, L.,Shi, P.,Tian, C. Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue. Cell Res., 32:858-861, 2022 Cited by PubMed: 35352031 DOI: 10.1038/s41422-022-00646-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.19 Å)

Structure validation