7X1U
Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide Agonist TRH.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004997 | molecular_function | thyrotropin-releasing hormone receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0019001 | molecular_function | guanyl nucleotide binding |
| B | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005834 | cellular_component | heterotrimeric G-protein complex |
| C | 0007165 | biological_process | signal transduction |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| C | 0016020 | cellular_component | membrane |
| C | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| C | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| C | 0071870 | biological_process | cellular response to catecholamine stimulus |
| C | 0097381 | cellular_component | photoreceptor disc membrane |
| F | 0003924 | molecular_function | GTPase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005834 | cellular_component | heterotrimeric G-protein complex |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0007165 | biological_process | signal transduction |
| F | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| F | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| F | 0016020 | cellular_component | membrane |
| F | 0031681 | molecular_function | G-protein beta-subunit binding |
| F | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| F | 0071870 | biological_process | cellular response to catecholamine stimulus |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASScSITAFTIERYIaI |
| Chain | Residue | Details |
| A | ALA111-ILE127 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| C | LEU70-SER84 | |
| C | ILE157-ILE171 | |
| C | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62873 |
| Chain | Residue | Details |
| C | SER2 | |
| A | THR84-LEU99 | |
| A | SER169-LEU193 | |
| A | ASN289-PHE296 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphohistidine => ECO:0000269|PubMed:12486123 |
| Chain | Residue | Details |
| C | HIS266 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 159 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG52-ASN61 | |
| A | GLU122-LYS144 | |
| A | ARG216-LYS266 | |
| A | TYR320-SER398 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS62-ILE83 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS100-ILE121 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE145-ILE168 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET194-ALA215 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET267-VAL288 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN297-ILE319 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN3 | |
| A | ASN10 |
