7X09

Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with inhibitors L95 and Halofuginone

7X09 の概要

• エントリーDOI: 10.2210/pdb7x09/pdb
• 分子名称: Bifunctional glutamate/proline--tRNA ligase, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide, ... (9 entities in total)
• 機能のキーワード: protein translation, inhibitor, prs, atp pocket, double drug, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117344.59

構造登録者

Manickam, Y.,Babbar, P.,Pillai, P.,Sharma, A. (登録日: 2022-02-21, 公開日: 2023-08-30)

• 主引用文献: Manickam, Y.,Babbar, P.,Sharma, A.; Crystal structure of Homo sapiens Prolyl-tRNA synthetase (HsPRS) with double inhibitors (HF and L95); To Be Published,

実験手法

X-RAY DIFFRACTION (1.7 Å)