7WZU

Crystal structure of metallo-beta-lactamase IMP-6.

Summary for 7WZU

Entry DOI	10.2210/pdb7wzu/pdb
Descriptor	Beta-lactamase, ZINC ION (3 entities in total)
Functional Keywords	metallo-beta-lactamase, zinc(ii) ion, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	4
Total formula weight	100989.86
Authors	Yamaguchi, Y.,Kurosaki, H. (deposition date: 2022-02-19, release date: 2023-01-04, Last modification date: 2023-11-29)
Primary citation	Yamaguchi, Y.,Kato, K.,Ichimaru, Y.,Uenosono, Y.,Tawara, S.,Ito, R.,Matsuse, N.,Wachino, J.I.,Toma-Fukai, S.,Jin, W.,Arakawa, Y.,Otsuka, M.,Fujita, M.,Fukuishi, N.,Sugiura, K.,Imai, M.,Kurosaki, H. Difference in the Inhibitory Effect of Thiol Compounds and Demetallation Rates from the Zn(II) Active Site of Metallo-beta-lactamases (IMP-1 and IMP-6) Associated with a Single Amino Acid Substitution. Acs Infect Dis., 9:65-78, 2023 Cited by PubMed: 36519431 DOI: 10.1021/acsinfecdis.2c00395 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.954 Å)

Structure validation