7WW2

Structure of an Isocytosine specific deaminase Vcz

Summary for 7WW2

• Entry DOI: 10.2210/pdb7ww2/pdb
• Descriptor: 8-oxoguanine deaminase, ZINC ION (3 entities in total)
• Functional Keywords: deaminase, isocytosine, cancer therapy, 5-fluorouracil, hydrolase
• Biological source: Obesumbacterium proteus
• Total number of polymer chains: 2
• Total formula weight: 99219.54

Authors

Li, X.J.,Wu, B.X. (deposition date: 2022-02-12, release date: 2023-02-22, Last modification date: 2023-09-20)

• Primary citation: Guo, W.,Li, X.,Fan, J.,Li, H.,Wen, Y.,Meng, C.,Chen, H.,Zhao, Z.,Zhang, Y.,Du, Y.,Wu, B.; Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy.; Iscience, 26:107672-107672, 2023; PubMed: 37680460; DOI: 10.1016/j.isci.2023.107672

Experimental method

X-RAY DIFFRACTION (2.7 Å)