7WVM

The complex structure of PD-1 and cemiplimab

Summary for 7WVM

• Entry DOI: 10.2210/pdb7wvm/pdb
• Descriptor: Heavy Chain of Cemiplimab, Light Chain of Cemiplimab, Programmed cell death protein 1 (3 entities in total)
• Functional Keywords: pd-1, antibody, n58 glycosylation, cemiplimab, immune checkpoint therapy (ict), antitumor protein, immune system-antitumor protein complex, immune system/antitumor protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 74873.37

Authors

Lu, D.,Xu, Z.P.,Liu, K.F.,Tan, S.G.,Gao, G.F.,Chai, Y. (deposition date: 2022-02-10, release date: 2022-04-20, Last modification date: 2023-11-29)

• Primary citation: Lu, D.,Xu, Z.,Zhang, D.,Jiang, M.,Liu, K.,He, J.,Ma, D.,Ma, X.,Tan, S.,Gao, G.F.,Chai, Y.; PD-1 N58-Glycosylation-Dependent Binding of Monoclonal Antibody Cemiplimab for Immune Checkpoint Therapy.; Front Immunol, 13:826045-826045, 2022; PubMed: 35309324; DOI: 10.3389/fimmu.2022.826045

Experimental method

X-RAY DIFFRACTION (3.4 Å)