7WV9

Allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 in complex with Gi protein

7WV9 の概要

• エントリーDOI: 10.2210/pdb7wv9/pdb
• EMDBエントリー: 32850
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: complex, agonist, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 170389.00

構造登録者

Xu, Z.,Shao, Z. (登録日: 2022-02-10, 公開日: 2022-06-15, 最終更新日: 2024-04-03)

• 主引用文献: Yang, X.,Wang, X.,Xu, Z.,Wu, C.,Zhou, Y.,Wang, Y.,Lin, G.,Li, K.,Wu, M.,Xia, A.,Liu, J.,Cheng, L.,Zou, J.,Yan, W.,Shao, Z.,Yang, S.; Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.; Nat.Chem.Biol., 18:831-840, 2022; PubMed: 35637350; DOI: 10.1038/s41589-022-01038-y

実験手法

ELECTRON MICROSCOPY (3.36 Å)