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7WPM

Methionyl-tRNA synthetase from Staphylococcus aureus complexed with a fragment and ATP

Summary for 7WPM
Entry DOI10.2210/pdb7wpm/pdb
DescriptorMethionine--tRNA ligase, ADENOSINE-5'-TRIPHOSPHATE, QUINOLIN-2-AMINE, ... (5 entities in total)
Functional Keywordsligase-inhibitor complex, ligase/inhibitor
Biological sourceStaphylococcus aureus subsp. aureus COL (Staphylococcus aureus COL)
Total number of polymer chains1
Total formula weight61817.39
Authors
Yi, J.,Cai, Z.,Qiu, H.,Lu, F.,Chen, B.,Luo, Z.,Gu, Q.,Xu, J.,Zhou, H. (deposition date: 2022-01-24, release date: 2022-04-27, Last modification date: 2023-11-29)
Primary citationYi, J.,Cai, Z.,Qiu, H.,Lu, F.,Luo, Z.,Chen, B.,Gu, Q.,Xu, J.,Zhou, H.
Fragment screening and structural analyses highlight the ATP-assisted ligand binding for inhibitor discovery against type 1 methionyl-tRNA synthetase.
Nucleic Acids Res., 50:4755-4768, 2022
Cited by
PubMed: 35474479
DOI: 10.1093/nar/gkac285
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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