7WM4
Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp)
Summary for 7WM4
Entry DOI | 10.2210/pdb7wm4/pdb |
EMDB information | 32599 |
Descriptor | Toll-like receptor 3, RNA (81-MER), beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | innate immunity, immune system, immune system-rna complex, immune system/rna |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 377646.32 |
Authors | Sakaniwa, K.,Ohto, U.,Shimizu, T. (deposition date: 2022-01-14, release date: 2023-01-25, Last modification date: 2024-10-16) |
Primary citation | Sakaniwa, K.,Fujimura, A.,Shibata, T.,Shigematsu, H.,Ekimoto, T.,Yamamoto, M.,Ikeguchi, M.,Miyake, K.,Ohto, U.,Shimizu, T. TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nat Commun, 14:164-164, 2023 Cited by PubMed: 36631495DOI: 10.1038/s41467-023-35844-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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