7WL4

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50

7WL4 の概要

• エントリーDOI: 10.2210/pdb7wl4/pdb
• 分子名称: Bromodomain-containing protein 4, ~{N}-[2-ethyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]-2,4-bis(fluoranyl)benzenesulfonamide (3 entities in total)
• 機能のキーワード: bromodomain, brd4(1), inhibitor, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69019.39

構造登録者

Zhang, C.,Wang, C.,Li, W.,Zhang, Y.,Xu, Y.,Sun, L. (登録日: 2022-01-12, 公開日: 2022-08-10, 最終更新日: 2023-11-29)

• 主引用文献: Li, W.,Zhang, C.,Zhang, H.E.,Dong, R.,Liu, J.Y.,Wang, C.M.,Wang, M.,Wang, Y.W.,Wang, C.,Zhang, Y.,Shi, L.,Xu, Y.,Sun, L.P.; Design, synthesis, and anticancer evaluation of ammosamide B with pyrroloquinoline derivatives as novel BRD4 inhibitors.; Bioorg.Chem., 127:105917-105917, 2022; PubMed: 35738217; DOI: 10.1016/j.bioorg.2022.105917

実験手法

X-RAY DIFFRACTION (1.82 Å)