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7WKZ

Crystal structure of the HSA complex with mycophenolate and aripiprazole

Summary for 7WKZ
Entry DOI10.2210/pdb7wkz/pdb
DescriptorSerum albumin, 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, MYCOPHENOLIC ACID (3 entities in total)
Functional Keywordsdrug, complex, transport protein
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight134679.88
Authors
Kawai, A.,Yamasaki, K. (deposition date: 2022-01-12, release date: 2022-12-28, Last modification date: 2023-11-29)
Primary citationYamasaki, K.,Teshima, H.,Yukizawa, R.,Kuyama, K.,Tsukigawa, K.,Nishi, K.,Otagiri, M.,Kawai, A.
Structural Basis of the Change in the Interaction Between Mycophenolic Acid and Subdomain IIA of Human Serum Albumin During Renal Failure.
J.Med.Chem., 66:951-961, 2023
Cited by
PubMed: 36538495
DOI: 10.1021/acs.jmedchem.2c01790
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.992 Å)
Structure validation

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