7WKI

Structure of the ultra-affinity complex between CFH and a nanobody

7WKI の概要

• エントリーDOI: 10.2210/pdb7wki/pdb
• 分子名称: Complement factor H, Anti-CFH nanobody (VHH) (3 entities in total)
• 機能のキーワード: ultra-high affinity; nanobody; atypical hemolytic uremic syndrome; complement system; autoantibody; autoimmune disease, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37160.48

構造登録者

Caaveiro, J.M.M.,Yokoo, T.,Tsumoto, K. (登録日: 2022-01-10, 公開日: 2022-11-23, 最終更新日: 2023-11-29)

• 主引用文献: Yokoo, T.,Tanabe, A.,Yoshida, Y.,Caaveiro, J.M.M.,Nakakido, M.,Ikeda, Y.,Fujimura, Y.,Matsumoto, M.,Entzminger, K.,Maruyama, T.,Okumura, C.J.,Nangaku, M.,Tsumoto, K.; Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis.; J.Biol.Chem., 298:101962-101962, 2022; PubMed: 35452676; DOI: 10.1016/j.jbc.2022.101962

実験手法

X-RAY DIFFRACTION (2.6 Å)